MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.
The objectives of MIMOmics are:
- to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers
- to integrate data derived from multiple omics platforms across several study designs and populations.
The following recurrent epidemiological questions will be answered:
- which molecular profiles are associated?
- can we identify subgroups of patients based on molecular profiles?
- which biological pathways play a role?
- which informative marker profiles within each population can be transferred across populations?
- are the identified molecular marker profiles causal?
To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health). Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software.